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Research articles
Adipose tissue retains an epigenetic memory of obesity after weight loss
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to the problematic ‘yo-yo’ effect often seen with dieting.
- Laura C. Hinte
- Daniel Castellano-Castillo
- Ferdinand von Meyenn
Lunar farside volcanism 2.8 billion years ago from Chang’e-6 basalts
- Qian W. L. Zhang
- Mu-Han Yang
- Xian-Hua Li
Engineered receptors for soluble cellular communication and disease sensing
- Dan I. Piraner
- Mohamad H. Abedi
- Kole T. Roybal
Photochemical permutation of thiazoles, isothiazoles and other azoles
- Baptiste Roure
- Maialen Alonso
- Daniele Leonori
Fluorspar to fluorochemicals upon low-temperature activation in water
Fluorochemicals are obtained directly from fluorspar activated in water at low temperature, without the requirement to manufacture hydrogen fluoride, a toxic and hazardous gas that is central to the current industrial process.
- Calum Patel
- Véronique Gouverneur
Clinical functional proteomics of intercellular signalling in pancreatic cancer
TMEPro profiles the glycosylated secreted and plasma membrane proteome of 100 human pancreatic tissue samples, defines cell type origins and identifies potential paracrine cross-talk mediated through tyrosine phosphorylation.
- Peiwu Huang
- Ruijun Tian
Foundation models for fast, label-free detection of glioma infiltration
FastGlioma is a visual foundation model for fast and accurate detection of glioma infiltration in fresh, unprocessed surgical tissue.
- Akhil Kondepudi
- Melike Pekmezci
- Todd Hollon
Prefrontal transthalamic uncertainty processing drives flexible switching
By examining neural responses from tree shrews performing hierarchical decision tasks with rule reversals, the authors identify a thalamocortical mechanism for regulating cognitive flexibility.
- Norman H. Lam
- Arghya Mukherjee
- Michael M. Halassa
Observation of Hilbert space fragmentation and fractonic excitations in 2D
Using quantum gas microscopy, Hilbert space fragmentation and fractonic excitations are observed in a two-dimensional tilted Bose–Hubbard model.
- Daniel Adler
- Johannes Zeiher
Task-agnostic exoskeleton control via biological joint moment estimation
A task-agnostic controller assists the user on the basis of instantaneous estimates of lower-limb biological joint moments from a deep neural network so exoskeletons can aid users across a broad spectrum of human activities.
- Dean D. Molinaro
- Keaton L. Scherpereel
- Aaron J. Young
Mapping the ionosphere with millions of phones
Data from millions of smartphones are used to map the ionosphere in greater detail, leading to improved smartphone location accuracy, particularly in parts of the world with few monitoring stations.
- Jamie Smith
- Brian P. Williams
Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1
Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their roles in maintaining epigenetic inheritance.
- Victoria Godínez López
- Marco Igor Valencia-Sánchez
- Karim-Jean Armache
NK2R control of energy expenditure and feeding to treat metabolic diseases
In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as well as by increasing insulin sensitivity.
- Frederike Sass
- Zachary Gerhart-Hines
Intravenous and intracranial GD2-CAR T cells for H3K27M + diffuse midline gliomas
We evaluated the use of chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) for H3K27M + diffuse midline glioma (DMG), finding that intravenous administration of GD2-CART, followed by intracranial infusions, induced tumour regressions and neurological improvements in patients with H3K27M-mutant pontine or spinal DMG.
- Michelle Monje
- Jasia Mahdi
- Crystal Mackall
Releasing a sugar brake generates sweeter tomato without yield penalty
A study identifies two genes that act as brakes controlling the sugar content of tomatoes and demonstrates their manipulation to generate sweeter tomatoes without affecting the fruit size and yield.
- Jinzhe Zhang
- Hongjun Lyu
- Sanwen Huang
Biodiversity impacts of the 2019–2020 Australian megafires
Data collected from more than 2,000 taxa provide an unparalleled opportunity to quantify how extreme wildfires affect biodiversity, revealing that the largest effects on plants and animals were in areas with frequent or recent past fires and within extensively burnt areas.
- Don A. Driscoll
- Kristina J. Macdonald
- Ryan D. Phillips
A combinatorial neural code for long-term motor memory
Long-term tracking of learned actions in mouse motor cortex shows that learned actions are retained with their context, and learning new tasks creates new memories, which do not overwrite or modify existing representations.
- Jae-Hyun Kim
- Kayvon Daie
Accelerated formation of ultra-massive galaxies in the first billion years
A study of 36 massive galaxies at redshifts between 5 and 9 from the JWST FRESCO survey finds that galaxy formation of the most massive galaxies is 2–3 times higher than the most efficient galaxies at later epochs.
- Mengyuan Xiao
- Pascal A. Oesch
- J. Stuart B. Wyithe
Dental evidence for extended growth in early Homo from Dmanisi
Fossil tooth development suggests an extended human growth phase occurred at least 1.77 million years ago, possibly reflecting a shift towards extended parenting and reproductive success, rather than increasing brain size.
- Christoph P. E. Zollikofer
- Vincent Beyrand
- Marcia S. Ponce de León
Entanglement and iSWAP gate between molecular qubits
Intrinsic molecular resources are used to implement a two-qubit iSWAP gate using individually trapped X 1 Σ + NaCs molecules.
- Lewis R. B. Picard
- Annie J. Park
- Kang-Kuen Ni
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